Bremelanotide — Cyclic Melanocortin Analogue — 10mg
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin agonist developed from Melanotan II. Unlike Melanotan I which acts selectively at MC1R, PT-141 acts primarily at MC3R and MC4R receptors in the central nervous system. Bremelanotide received FDA approval in 2019 under the brand name Vyleesi for hypoactive sexual desire disorder. Studied in laboratory models for CNS melanocortin pathway pharmacology and reproductive neuroscience. Independently verified at 99.874% purity by Janoshik Analytical.
55.00
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Batch PLB-012 · Janoshik Analytical · 99.874% purity confirmed
About PT-141
PT-141 (Bremelanotide) is a cyclic heptapeptide developed from Melanotan II through the removal of the C-terminal amide group. Unlike Melanotan I which selectively targets MC1R in peripheral tissue, PT-141 acts centrally at MC3R and MC4R receptors in the hypothalamus and limbic system, producing distinct CNS-mediated effects.
Bremelanotide received FDA approval in June 2019 under the brand name Vyleesi (AMAG Pharmaceuticals) for the treatment of hypoactive sexual desire disorder in premenopausal women — making it the first melanocortin compound to receive full regulatory approval for a CNS-mediated indication.
All Pureline Biolabs PT-141 is supplied as a lyophilised powder in sealed vials, independently tested by Janoshik Analytical at 99.874% purity.
Product Specifications
| Compound | PT-141 |
| Also known as | Bremelanotide · Vyleesi |
| Primary receptors | MC3R · MC4R (CNS) |
| Structure | Cyclic heptapeptide |
| Molecular weight | 1025.2 g/mol |
| Vial size | 10mg lyophilised powder |
| Purity | 99.874% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | GMP Registered Facility |
| Batch | PLB-012 |
| Research use only | Not for human consumption |
Research Background
PT-141 has been studied extensively in CNS melanocortin pharmacology, reproductive neuroscience and melanocortin receptor biology research. This product is supplied for laboratory research purposes only.
Studies have characterised PT-141’s binding affinity and functional activity at MC3R and MC4R receptors, comparing its pharmacological profile to other melanocortin agonists and examining receptor subtype selectivity in CNS tissue models.
Laboratory models have investigated PT-141’s effects on hypothalamic melanocortin circuitry, examining how MC4R activation in the paraventricular nucleus and other hypothalamic regions modulates autonomic nervous system output.
Studies have examined PT-141’s role in the broader melanocortin system, investigating interactions with endogenous melanocortin ligands, agouti-related protein (AgRP) and the downstream signalling consequences of MC3R/MC4R co-activation.
Comparative studies have examined the receptor selectivity profile of PT-141 versus Melanotan I and Melanotan II, characterising the pharmacological implications of cyclic versus linear structure and the resulting CNS versus peripheral activity distribution.
Research has investigated MC4R’s role in energy homeostasis and how PT-141’s MC4R activation affects food intake regulation, energy expenditure and body weight in rodent models — separate from its reproductive effects.
Studies have examined PT-141’s cardiovascular effects including its transient blood pressure-modulating properties, investigating the mechanism of action and dose-response relationship in animal models.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen as lyophilised powder.
Keep away from UV and direct light. Store in original packaging.
Reconstitution Guide
PT-141 is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications.
Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall — not directly onto the powder.
Gently swirl until powder fully dissolves. Do not shake. Solution should be clear and colourless.
Use our Reconstitution Calculator → for exact volumes.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.com
