Bremelanotide — Cyclic Melanocortin Analogue — 10mg
Buy PT-141 UK from Pureline Biolabs. PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin agonist derived from Melanotan II, with activity mainly at the MC3R and MC4R receptors. Supplied as lyophilised powder for laboratory research and studied in melanocortin receptor pharmacology. Independently verified at 99.874% purity by Janoshik Analytical.
55.00
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Batch PLB-012 · Janoshik Analytical · 99.874% purity confirmed
About PT-141
PT-141 (bremelanotide) is a cyclic heptapeptide developed from Melanotan II. Unlike Melanotan I, which is selective for MC1R, PT-141 acts mainly at MC3R and MC4R, receptors expressed in the hypothalamus and limbic system.
Bremelanotide is also the active substance in an FDA-approved medicine (Vyleesi, 2019). That approval covers the licensed product only and does not apply to research-grade material. The published research is reviewed on our PT-141 compound profile.
All Pureline Biolabs PT-141 is supplied as a lyophilised powder in sealed vials, independently tested by Janoshik Analytical at 99.874% purity.
Product Specifications
| Compound | PT-141 |
| Also known as | Bremelanotide · Vyleesi |
| Primary receptors | MC3R · MC4R (CNS) |
| Structure | Cyclic heptapeptide |
| Molecular formula | C50H68N14O10 |
| Molecular weight | 1025.18 g/mol |
| CAS number | 189691-06-3 (free peptide) |
| PubChem CID | 9941379 |
| Vial size | 10mg lyophilised powder |
| Purity | 99.874% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | Batch-Tested on Receipt |
| Batch | PLB-012 |
| Research use only | Not for human consumption |
Research Background
PT-141 has been studied in melanocortin receptor pharmacology and hypothalamic signalling research. The areas below describe what studies measured, not established effects. For the full evidence review, see the PT-141 compound profile. This product is supplied for laboratory research purposes only.
Studies have measured binding affinity and functional activity at MC3R and MC4R compared with other melanocortin agonists.
Animal studies have mapped MC4R signalling in the paraventricular nucleus and other hypothalamic regions.
Studies have examined interactions with endogenous melanocortin ligands and agouti-related protein (AgRP).
Comparative studies have measured selectivity against Melanotan I and Melanotan II, including cyclic versus linear structure.
Rodent studies of MC4R signalling have used food intake and energy expenditure as experimental endpoints.
Animal and clinical studies have measured transient blood-pressure changes.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen as lyophilised powder.
Keep away from UV and direct light. Store in original packaging.
Reconstitution Guide
PT-141 is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications.
Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall — not directly onto the powder.
Gently swirl until powder fully dissolves. Do not shake. Solution should be clear and colourless.
Use our Reconstitution Calculator → for exact volumes.
Buying PT-141 in the UK — common questions
What purity is Pureline’s PT-141, and who tested it?
Batch PLB-012 was reported at 99.874% by HPLC at Janoshik Analytical, with LC-MS supporting the assigned molecular identity. That is an area-percent figure under the laboratory’s stated method — chromatographic purity of the tested sample, not a statement about biological activity. The COA verification guide shows how to check a report like this yourself.
How much bacteriostatic water does a 10mg PT-141 vial need?
2ml gives 5 mg/ml and 3ml gives roughly 3.33 mg/ml — mass divided by volume. The reconstitution calculator has this vial loaded, and the reconstitution guide covers aliquoting and the losses that the arithmetic does not show.
What is the relationship between PT-141 and the melanotan peptides?
PT-141, also called bremelanotide, is a cyclic heptapeptide that arose from work on melanocortin analogues and is studied for its activity at the MC3R and MC4R receptors. Melanotan I is a linear α-MSH analogue with a different receptor profile. Related research lineage, different molecules, different literature — not interchangeable.
Does the cyclic structure change how it should be handled?
The lactam bridge makes the molecule more conformationally constrained and generally more resistant to enzymatic breakdown than an equivalent linear sequence, which is part of why it was developed. It still degrades in solution: keep it cold, keep it dark, and aliquot. The half-life and degradation guide explains the mechanisms.
How should PT-141 be stored?
Sealed and lyophilised at 2–8°C, protected from light; it ships cold chain from the UK. Once reconstituted, refrigerate at 2–8°C and aliquot into single-use portions before freezing so the stock takes one freeze-thaw cycle rather than one per use. Allow a closed vial to reach room temperature before opening.
Can I see the Certificate of Analysis before I order?
Yes. Every batch report is published on our independent lab reports page before the stock is listed, and the batch number on the report matches the number printed on your vial. The label carries a QR code that opens the report on Janoshik’s own verification server.
Is PT-141 legal to buy in the UK?
Pureline supplies it strictly as a research chemical for in vitro laboratory use. Whatever authorisations bremelanotide holds in other jurisdictions, this material is not a licensed medicine in the UK, carries no marketing authorisation here, and is not sold or supplied by us for human or veterinary use. We cover this in full in is PT-141 legal in the UK, and the UK peptide law guide sets out how research-use materials sit within the regulations generally.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.com
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