Afamelanotide — Linear α-MSH Analogue — 10mg
Buy Melanotan I UK from Pureline Biolabs. Melanotan I (afamelanotide) is a synthetic linear analogue of alpha-melanocyte stimulating hormone (α-MSH), developed at the University of Arizona. Supplied as lyophilised powder for laboratory research and studied in MC1R receptor and pigmentation-biology research. Independently verified at 99.805% purity by Janoshik Analytical.
34.99
Inc. VAT · Free UK delivery over £75
Batch PLB-005 · Janoshik Analytical · 99.805% purity · 8.13mg measured content
About Melanotan I
Melanotan I (Afamelanotide) is a synthetic 13-amino acid linear analogue of alpha-melanocyte stimulating hormone (α-MSH), developed by Victor Hruby and colleagues at the University of Arizona. It was designed to be a more potent and stable version of natural α-MSH with selective MC1R agonist activity.
The key structural modifications — substitution of methionine with norleucine and replacement of L-phenylalanine with D-phenylalanine — increase receptor binding affinity, resistance to enzymatic degradation and biological half-life while maintaining the linear peptide structure.
Afamelanotide is also the active substance in an authorised medicine (Scenesse, Clinuvel Pharmaceuticals). That authorisation covers the licensed implant only and does not apply to research-grade material. The published research is reviewed on our Melanotan I compound profile. All Pureline Biolabs Melanotan I is independently tested by Janoshik Analytical at 99.805% purity.
Product Specifications
| Compound | Melanotan I |
| Also known as | Afamelanotide · Scenesse · MT-1 |
| Primary receptor | MC1R (selective) |
| Structure | Linear — 13 amino acids |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.87 g/mol |
| CAS number | 75921-69-6 (free peptide) |
| PubChem CID | 16197727 |
| Vial size | 10mg nominal, lyophilised powder |
| Measured content | 8.13mg — batch PLB-005, Janoshik task #209939 |
| Purity | 99.805% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | Batch-Tested on Receipt |
| Batch | PLB-005 |
| Research use only | Not for human consumption |
Research Background
Melanotan I has been studied in melanocortin receptor pharmacology and pigmentation-biology research. The areas below describe what studies measured, not established effects. For the full evidence review, see the Melanotan I compound profile. This product is supplied for laboratory research purposes only.
Studies have measured binding affinity and cAMP signalling at MC1R versus other melanocortin receptor subtypes.
Cell and clinical studies have measured melanin synthesis, including eumelanin and phaeomelanin production.
Studies have measured erythema and DNA-damage markers in UV exposure models.
Studies have examined how the norleucine and D-phenylalanine substitutions affect receptor binding and enzymatic stability.
Comparative studies have measured selectivity at MC1R versus MC3R and MC4R, compared with Melanotan II.
Some cell studies have measured NF-κB activation and cytokine production linked to MC1R signalling.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen.
Being a melanocortin compound, protect from all light sources. Handle in reduced light conditions.
Reconstitution Guide
Melanotan I is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications. Handle in reduced light conditions throughout.
Work in reduced light. Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall. Keep away from direct light throughout.
Gently swirl until powder fully dissolves. Solution should be clear and colourless. Store immediately at 2–8°C in reduced light.
Use our Reconstitution Calculator → for exact volumes.
Customer Reviews
Buying Melanotan I in the UK — common questions
How much Melanotan I is actually in the vial?
Janoshik measured 8.13mg of peptide in the 10mg vial for batch PLB-005. Vial masses across this industry are nominal fill targets, and lyophilised material also carries counter-ion and residual water that the peptide content figure excludes. We publish the measured number because it is the one your calculations should use — a supplier who only quotes the label is quoting a target, not a result.
What purity is Pureline’s Melanotan I, and who tested it?
Batch PLB-005 was reported at 99.805% by HPLC at Janoshik Analytical. Purity and content are two separate measurements: purity says how much of what is in the vial is the intended compound, content says how many milligrams of it there are. The purity figures guide works through why both matter.
How much bacteriostatic water does a Melanotan I vial need?
Calculate from the 8.13mg measured content, not the 10mg label: 2ml gives roughly 4.07 mg/ml, and 1ml gives roughly 8.13 mg/ml. Our reconstitution calculator has this batch loaded with the certificated figure, and the reconstitution guide covers aliquoting and freeze-thaw losses.
What is the difference between Melanotan I and Melanotan II?
Melanotan I, also called afamelanotide, is a linear 13-residue analogue of α-MSH. Melanotan II is a shorter cyclic analogue with a different receptor selectivity profile, and the two are studied for different questions in melanocortin receptor pharmacology. They are not variants of one another and the literature on each does not transfer to the other. Pureline supplies Melanotan I only.
How should Melanotan I be stored?
Sealed and lyophilised at 2–8°C, protected from light; it ships cold chain from the UK. Once reconstituted, keep it refrigerated at 2–8°C and aliquot into single-use portions before freezing, so the stock sees one freeze-thaw cycle rather than one per use. Allow a closed vial to reach room temperature before opening.
Can I see the Certificate of Analysis before I order?
Yes. Every batch report is published on our independent lab reports page before the stock is listed, and the batch number on the report matches the number printed on your vial. The label also carries a QR code that opens the report on Janoshik’s own verification server.
Is Melanotan I legal to buy in the UK?
It is supplied strictly as a research chemical for in vitro laboratory use. Melanotan I is not a licensed medicine in the UK, it holds no marketing authorisation here, and it is not sold or supplied by us for human or veterinary use in any form. The UK peptide law guide sets out how research-use materials sit within the regulations.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.com
Reviews
There are no reviews yet