Pureline Biolabs Ltd supplies research grade compounds strictly for laboratory and in vitro research purposes. Please confirm the following before proceeding.
Pureline Biolabs Ltd · Company No. 17236739 · Registered in England & Wales · Not evaluated by the MHRA
Ipamorelin is a selective pentapeptide growth hormone secretagogue and ghrelin receptor (GHS-R1a) agonist studied in laboratory models for its ability to stimulate clean GH pulse secretion with minimal effect on cortisol, prolactin or ACTH — making it uniquely selective versus older generation GH secretagogues. The most widely used GH secretagogue in research, most commonly paired with CJC-1295 No DAC. Third-party verified at ≥99% purity by Janoshik Analytical.
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and selective agonist at the growth hormone secretagogue receptor type 1a (GHS-R1a). It was developed by Novo Nordisk in the late 1990s and represents the third generation of GH secretagogues — characterised by its exceptional selectivity for GH release with minimal stimulation of other pituitary hormones.
Unlike first-generation secretagogues such as GHRP-2 and GHRP-6 which produce significant cortisol, prolactin and ACTH elevations, Ipamorelin produces clean, selective GH pulses that more closely mimic the natural pulsatile GH release pattern. This selectivity makes it particularly valuable for research investigating GH axis physiology without confounding effects on the stress hormone axis.
All Pureline Biolabs Ipamorelin is supplied as a lyophilised powder in sealed vials, third-party tested by Janoshik Analytical with certificates available on our Lab Reports page.
| Compound | Ipamorelin |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Receptor | GHS-R1a (ghrelin receptor) |
| Amino acids | 5 (pentapeptide) |
| Molecular weight | 711.9 g/mol |
| Vial size | 5mg lyophilised powder |
| Purity | ≥99% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | GMP Registered Facility |
| Batch | PLB-001 |
| Research use only | Not for human consumption |
Ipamorelin is one of the most widely studied GH secretagogues in research literature. This product is supplied for laboratory research purposes only.
Studies have characterised Ipamorelin's exceptional selectivity for GH release versus cortisol, prolactin and ACTH, comparing its hormonal profile to earlier generation secretagogues (GHRP-2, GHRP-6) and demonstrating cleaner GH pulse stimulation.
Research has extensively examined the synergistic combination of Ipamorelin with CJC-1295 No DAC, demonstrating that simultaneous GHRH receptor and GHS-R1a activation produces significantly amplified GH pulses versus either compound alone.
Laboratory models have examined Ipamorelin's effects on lean mass, fat distribution and body composition via GH pulse stimulation, measuring downstream IGF-1 responses and tissue-level anabolic and lipolytic effects.
Studies have investigated Ipamorelin's gastrointestinal effects, examining its ability to accelerate gastric emptying via GHS-R1a receptors in the gut — an effect distinct from its pituitary GH secretagogue activity.
Research has examined GH pulse stimulation effects on bone mineral density and bone formation markers in aged animal models, investigating whether Ipamorelin-stimulated GH pulses can support bone health via IGF-1 mediated pathways.
Comparative studies have measured cortisol responses following Ipamorelin versus GHRP-2 and GHRP-6, quantifying the degree of HPA axis sparing and characterising Ipamorelin's pharmacological profile as a selective GH secretagogue.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen.
Keep away from UV and direct light. Store in original packaging.
Ipamorelin is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications.
Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall — not directly onto the powder.
Gently swirl until powder fully dissolves. Do not shake. Solution should be clear and colourless. Ipamorelin dissolves readily.
Use our Reconstitution Calculator → for exact volumes.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.co.uk