Pureline Biolabs Ltd supplies research grade compounds strictly for laboratory and in vitro research purposes. Please confirm the following before proceeding.
Pureline Biolabs Ltd · Company No. 17236739 · Registered in England & Wales · Not evaluated by the MHRA
Melanotan I (Afamelanotide) is a synthetic linear analogue of alpha-melanocyte stimulating hormone (α-MSH), developed at the University of Arizona. It acts primarily at the MC1R receptor with high selectivity, studied in laboratory models for melanocortin receptor activation, pigmentation biology and photoprotection mechanisms. Afamelanotide received EMA approval under the brand name Scenesse for erythropoietic protoporphyria. Independently verified at 99.805% purity by Janoshik Analytical.
Melanotan I (Afamelanotide) is a synthetic 13-amino acid linear analogue of alpha-melanocyte stimulating hormone (α-MSH), developed by Victor Hruby and colleagues at the University of Arizona. It was designed to be a more potent and stable version of natural α-MSH with selective MC1R agonist activity.
The key structural modifications — substitution of methionine with norvaline and replacement of L-phenylalanine with D-phenylalanine — increase receptor binding affinity, resistance to enzymatic degradation and biological half-life while maintaining the linear peptide structure.
Afamelanotide received European Medicines Agency (EMA) approval in 2014 under the brand name Scenesse (Clinuvel Pharmaceuticals) for erythropoietic protoporphyria. All Pureline Biolabs Melanotan I is independently tested by Janoshik Analytical at 99.805% purity.
| Compound | Melanotan I |
| Also known as | Afamelanotide · Scenesse · MT-1 |
| Primary receptor | MC1R (selective) |
| Structure | Linear — 13 amino acids |
| Molecular weight | 1646.9 g/mol |
| Vial size | 10mg lyophilised powder |
| Purity | 99.805% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | GMP Registered Facility |
| Batch | PLB-005 |
| Research use only | Not for human consumption |
Melanotan I has been studied extensively in pigmentation biology, photoprotection and melanocortin receptor pharmacology research. This product is supplied for laboratory research purposes only.
Studies have characterised Melanotan I's binding affinity and selectivity at MC1R versus other melanocortin receptor subtypes, examining receptor activation kinetics, cAMP signalling and downstream melanogenesis cascade activation.
Laboratory and clinical studies have investigated Melanotan I's ability to increase melanin synthesis and skin pigmentation, examining the dose-response relationship between receptor activation and eumelanin versus phaeomelanin production.
Research has examined Melanotan I's photoprotective effects in UV exposure models, measuring erythema reduction, DNA damage markers and keratinocyte apoptosis — the basis for its clinical approval in EPP.
Clinical trials demonstrated Melanotan I's efficacy in erythropoietic protoporphyria, measuring pain-free time in sunlight and phototoxic reaction incidence — leading to EMA approval as Scenesse in 2014.
Comparative studies have examined Melanotan I versus Melanotan II receptor selectivity profiles, characterising the implications of MC1R selectivity for isolating pigmentation research from CNS effects.
Some laboratory studies have investigated MC1R-mediated anti-inflammatory effects of Melanotan I, examining its effects on NF-κB activation, cytokine production and inflammatory cell function.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen.
Being a melanocortin compound, protect from all light sources. Handle in reduced light conditions.
Melanotan I is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications. Handle in reduced light conditions throughout.
Work in reduced light. Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall. Keep away from direct light throughout.
Gently swirl until powder fully dissolves. Solution should be clear and colourless. Store immediately at 2–8°C in reduced light.
Use our Reconstitution Calculator → for exact volumes.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.com