Pureline Biolabs Ltd supplies research grade compounds strictly for laboratory and in vitro research purposes. Please confirm the following before proceeding.
Pureline Biolabs Ltd · Company No. 17236739 · Registered in England & Wales · Not evaluated by the MHRA
Semax is a synthetic heptapeptide analogue of the ACTH(4-7) fragment developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Studied extensively in laboratory models for BDNF and NGF upregulation, neuroprotection, cognitive enhancement and anti-anxiety effects. The classic research pairing with Selank. Registered as a pharmaceutical drug in Russia. Third-party verified at ≥99% purity by Janoshik Analytical.
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, based on the ACTH(4-7) fragment of adrenocorticotropic hormone with a C-terminal Pro-Gly-Pro extension to improve stability and extend biological activity. It was developed alongside Selank as part of Russia's neuropeptide research programme and has been registered as a pharmaceutical drug in Russia.
Semax's primary studied mechanism is the upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) — key proteins responsible for neuronal growth, maintenance and synaptic plasticity. Unlike direct stimulant nootropics, Semax acts through neurotrophic pathways to support neuronal health and cognitive function in laboratory models. It is the classic research pairing with Selank — the two compounds having complementary anxiolytic and cognitive-enhancing mechanisms.
All Pureline Biolabs Semax is supplied as a lyophilised powder in sealed vials, third-party tested by Janoshik Analytical with certificates available on our Lab Reports page.
| Compound | Semax |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Origin | ACTH(4-7) analogue (Russian Academy) |
| Amino acids | 7 (heptapeptide) |
| Molecular weight | 813.9 g/mol |
| Available sizes | 5mg and 10mg |
| Purity | ≥99% — Janoshik verified |
| Form | Lyophilised powder, sealed vial |
| Manufacturing | GMP Registered Facility |
| Batch | PLB-001 |
| Research use only | Not for human consumption |
Semax has been studied extensively in Russian research institutions with a significant published literature across neuroprotective, cognitive and neurotrophic research. This product is supplied for laboratory research purposes only.
Studies have demonstrated Semax's ability to significantly upregulate BDNF expression in hippocampal and cortical neurons, examining the mechanisms by which ACTH fragment signalling activates neurotrophic factor synthesis and the downstream effects on neuronal survival and synaptic plasticity.
Laboratory research has investigated Semax's upregulation of nerve growth factor in brain regions, examining its effects on cholinergic neuron function, axonal growth and the neuroprotective implications for models of neurodegeneration.
Studies have examined Semax's neuroprotective effects in stroke and ischaemia models, measuring neuronal survival rates, infarct volume reduction and functional recovery following cerebral ischaemia in rodent models pre- and post-treated with Semax.
Laboratory models have examined Semax's effects on learning consolidation, memory retrieval and attention in rodent cognitive tasks, investigating the relationship between BDNF upregulation and improved performance in Morris water maze and other paradigms.
Studies have investigated Semax's effects on dopaminergic neurotransmission in the prefrontal cortex and striatum, examining its ability to modulate dopamine turnover and receptor sensitivity in cognitive performance models.
The classic Semax/Selank combination has been studied in multiple protocols examining complementary mechanisms — Semax providing neurotrophic and cognitive support while Selank contributes anxiolytic and GABAergic modulation — with studies examining synergistic neuroprotective effects.
Store in refrigerator. Keep away from direct light and heat sources.
Use within 28 days. Do not refreeze once reconstituted.
Stable for up to 24 months when frozen.
Keep away from UV and direct light. Store in original packaging.
Semax is supplied as a lyophilised powder and must be reconstituted with bacteriostatic water before use in research applications. Semax may also be prepared for intranasal research delivery — a common administration route in published Russian studies.
Allow vial to reach room temperature. Clean the rubber stopper with an alcohol swab and allow to dry completely.
Draw required volume of BAC water into a sterile syringe. Inject slowly down the inside of the vial wall — not directly onto the powder.
Gently swirl until powder fully dissolves. Do not shake. Solution should be clear and colourless. Semax dissolves readily in BAC water.
Use our Reconstitution Calculator → for exact volumes.
All products sold by Pureline Biolabs Ltd are intended strictly for laboratory research purposes only. Not approved for human consumption, veterinary use, or any other application. Not evaluated by the MHRA or any other regulatory authority. Pureline Biolabs Ltd · Company No. 17236739 · purelinebiolabs.co.uk